Zhuo Yu-xiang
2009
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Journal
Journal of Guangdong Pharmaceutical College
Abstract
Objective To evaluate the effect of microwave irradiation on the synthesis of 7-nitro-4(3H)-quinazolinone was investigated.Method 7-nitro-4(3H)-quinazolinone was synthesized from 4-nitroanthranilic acid and formamide under microwave irradiation.The reaction conditions were optimized with orthogonal design.Result The optimum conditions were determined as follows: microwave power was 95 W,irradiation time was 9 min,and the molar ratio of 4-nitroanthranilic acid to formamide was 1∶12.Under above conditions,the yield of product might reach 96.8%,increasing by 35% compared with conventional method.Conclusion 7-nitro-4(3H)-quinazolinone was synthesized successfully under microwave irradiation.Compared with conventional method,the reaction time shortened and the reaction efficiency increased.