Romain Paoli-Lombardo, N. Primas, Sandra Bourgeade-Delmas
Dec 19, 2023
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Journal
Synthesis
Abstract
To study the antikinetoplastid structure-activity relationships in 3-nitroimidazo[1,2-a]pyridine series, we explored the substitution of positions 5 and 7 of the scaffold, developing nucleophilic aromatic substitution reactions and pallado-catalyzed Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig cross-coupling reactions which had never been reported at these positions in this series. Thirty-three original compounds were obtained in 4 steps from 2-amino-bromopyridines, allowing a better definition of the antiparasitic pharmacophore.