H. Behbehani, H. M. Ibrahim, S. Makhseed
May 31, 2010
Citations
1
Influential Citations
14
Citations
Journal
Arkivoc
Abstract
A variety of new pyrazolo[1,5-a]pyrimidines has been prepared as potential drugs for the treatment of insomnia. The general synthetic route used for this purpose involves the condensation of substituted cyanoacetamides 5a-c, prepared by reaction of cyanoacetic acid with amines in presence of acetic anhydride, with dimethylformamide dimethylacetal and subsequent treatment of the formed enamines 6 with hydrazine hydrate. This process affords the corresponding aminopyrazole carboxamides 9 that react with the enaminonitrile 12 to generate the targets. Structures of the substance prepared in these sequences were established by using spectroscopic methods, including N HMBC and NOE difference experiments, as well as X-raycrystallographic analysis.