R. Singh, S. Jain, N. Sinha
Jan 22, 2007
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
8-Methyl-3,8-diazabicyclo[3.2.1]octane (3-azatropane) is synthesized efficiently from pyroglutamic acid making use of amide activation. The key step of the synthesis involves reduction and cyclization of a nitroenamine intermediate. Several 3-substituted analogues of this azatropane were also synthesized via this methodology and evaluated for their affinity at D2 and 5-HT2A receptors.