P. Raboisson, Dominique Schultz, C. Lugnier
Dec 23, 2002
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient two-step synthesis of 8-acylated pyrazolo[1,5- a ]-1,3,5-triazines has been accomplished. The key strategic elements of this novel synthetic approach involve the use of the N -methyl- N -phenylamino activating group, which was easily obtained in high yield by treatment of the pyrazolotriazin-4-one with phosphorus oxychloride and dimethylaniline through high pressure reaction coupled with a regioselective acylation at position 8 followed by the subsequent displacement of the N -methyl- N -phenylamino group upon treatment with various amines.