H. Matsumoto, C. Kaneko, K. Yamada
Mar 25, 1988
Citations
0
Influential Citations
35
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
A convenient and economical synthesis of 9-(2-hydroxyethoxymethyl)guanine (1, acyclovir, Zovirax, or acyclic guanosine : an antiherpetic agent)from guanine was developed via N2, O-diacetylacyclovir. Two closely related compounds, N2-acetylacyclovir (7) and O-acetylacyclovir (8), were also prepared by selective deacetylation.