P. Alexander, A. Holý, M. Masojídková
1987
Citations
1
Influential Citations
116
Citations
Quality indicators
Journal
Collection of Czechoslovak Chemical Communications
Abstract
Alkyl 2-chloroethoxymethyl(diethoxymethyl)phosphinates VII and XIII were prepared by reaction of silyl esters of dialkoxymethylphosphinic acid with 2-chloroethyl chloromethyl ether. Adenine was alkylated with VII and XIII to give [2-(adenin-9-yl)ethoxy]methyl(diethoxymethyl)phosphinates VIII and XIV , bearing the dialkoxymethyl protecting group on the phosphorus atom. Acid hydrolysis of compounds VIII and XIV afforded 9-(2-phosphinoethoxymethyl)adenine ( X ). Alkyl dialkoxymethylphosphinates V and XI reacted with paraformaldehyde to give hydroxymethylphosphinates XV and XIX which were converted into the synthons XVI , XVII and XVIII capable of introducing a protected hydroxymethylphosphino group on a hydroxy or amino group.