Z. Guo, S. Vangapandu, A. Nimrod
2005
Citations
0
Influential Citations
7
Citations
Journal
Medicinal chemistry (Shariqah (United Arab Emirates))
Abstract
Bruceantin (1), a classical quassinoid with the highest reported antimalarial activity among the quassinoids examined thus far, was selected as a natural product lead for the design of a series of A/B-ring analogs. A viable strategy for the synthesis of the series was developed. The functionalized A-ring and the C-15 ester moiety in bruceantin are incorporated in all designed compounds. The preliminary bioassay results will be discussed in detail.