H. Fujiwara, Taichi Kurogi, S. Okaya
Dec 21, 2012
Citations
0
Influential Citations
48
Citations
Journal
Angewandte Chemie
Abstract
The key step in this total synthesis of (-)-acetylaranotin is the efficient formation of the characteristic dihydrooxepine ring from cyclohexenone through an unusual vinylogous Rubottom oxidation and a regioselective Baeyer-Villiger oxidation. (-)-Acetylaranotin is obtained in 22 steps from commercially available L-Cbz-tyrosine (Cbz=benzyloxycarbonyl).