Pan Hai
2001
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Synthetic Chemistry
Abstract
Starting from cyclohexyl bromide, the cyclohexylacetic acid([ST5HZ]4) was obtained via condensation with diethyl malonate by means of sodium alcoholate, hydrolysis, acidification and decarboxylation. The bromination and aminolysis of [ST5HZ](4)[ST5BZ] afforded the DL cyclohexyl glycine, which was acetylated with acetic anhydride in acetic acid, giving the acetyl DL cyclohexyl glycine, a important intermediate of a COX 2 selective inhibitor, JTE 522. The target molecules structure has been characterized by element analysis,IR and NMR.