Satoshi Takita, S. Yokoshima, T. Fukuyama
Mar 21, 2011
Citations
0
Influential Citations
32
Citations
Journal
Organic letters
Abstract
A highly practical stereoselective total synthesis of (-)-kainic acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerizaion. This synthetic route enabled us to obtain 14.6 g of (-)-kainic acid.