N. Senthilkumar, Y. S. Somannavar, S. B. Reddy
Dec 15, 2010
Citations
0
Influential Citations
9
Citations
Journal
Synthetic Communications
Abstract
A simple synthetic route for active metabolites of carvedilol is reported. The metabolites 4′-hydroxycarvedilol and 5′-hydroxycarvedilol have exhibited high activity for β-blockade. We have disclosed syntheses of 4′-hydroxycarvedilol and 5′-hydroxycarvedilol from commercially available vanillin and isovanillin, respectively.