E. Chalina, Lidia Chakarova
Dec 1, 1998
Citations
0
Influential Citations
30
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract A series of new 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues was synthesized from corresponding 3-amino-1,2,3,4-tetrahydronaphthalenes. Pharmacological tests showed that compounds 3-ethyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)urea 2a and 3-ethyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)-3-morpholinomethylurea 3a possessed pronounced hypotensive and antiarrhythmic activities, as tested in anesthetized rats.