N. Lebouvier, F. Pagniez, M. Duflos
Jul 1, 2007
Citations
0
Influential Citations
65
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of fluconazole analogues 5-20 incorporating azaindole and indole moieties were prepared using oxirane intermediates synthesized under microwave irradiation. All of the compounds were evaluated in vitro against two clinically important fungi, Candida albicans and Aspergillus fumigatus. Four derivatives 6, 13, 14 and 18 exerted high antifungal activity against C. albicans with MIC(80) values 3- to 28-fold lower than that of fluconazole.