Gong Ping
2012
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
Journal of Shenyang Pharmaceutical University
Abstract
Objective To design and synthesize 2-substituted-4-aminothieno[3,2-d]pyrimidine derivatives and evaluate their in vitro antiproliferative activities.Methods The target compounds w ere synthesized in 6 steps starting from 3-aminothiophene-2-carboxylate,and their antiproliferative activity against H-460 and HT29 cancer cell lines w ere tested by MTT assay,w ith CP-31398 as the positive control.Results and Conclusion Sixteen compounds which had not been reported in literatures were synthesized,and their structures w ere confirmed by 1 H-NMR and MS.Five compounds show ed potent antiproliferative activity,and compound 8n displayed promising activity w hich w as 4-to 5-fold better than CP-31398,respectively.