Gong Ping
2008
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Influential Citations
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Citations
Quality indicators
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To design and synthesize 4-substituted piperazinylphenyloxazolidinone-indole carboxylate hybrids,and evaluate their antibacterial activities in vitro primarily.Methods The title compounds were synthesized in two steps with the starting material (S)-N-((3-(3-fluoro-4-(piperazin-1-yl)-phenyl)-2-oxo-oxazolidin-5-yl)methyl) acetamide,and their in vitro antibacterial activity were examined using MH broth dilution method.Results and conclusion Fourteen new compounds were prepared and their structures were confirmed by 1H-NMR and MS.Seven of them show antibacterial activity,while compounds 3a and 4b display promising activity and are worth further studying.