Liu Chun-xin
2013
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Journal
Applied Chemical Industry
Abstract
A benign process for synthesis of 1,2-benzisothiazoline-3-one has been achieved by reaction of chlorobenzonitrile and sodium methyl mercaptide with sulfuryl chloride in chlorobenzene,and 1,2-bis(3-oxobenzo[d]isothiazol-2(3H)-yl)ethane-1,2-dione has been achieved by reaction of the BIT/K salt and sodium chloroacetate in dichloromethane.The structures are characterized by 1H NMR spectra and IR,and the bacteriostatic activity test of the compounds,the results showed that the compound minimum inhibition concentration up to 8 μg/mL.