S. A. Demchenko, O. E. Iadlovskyi, L. Bobkova
2012
Citations
0
Influential Citations
1
Citations
Journal
Farmatsevtychnyĭ zhurnal
Abstract
There was synthesized a series of new [1,3]thiazolo-[4,5-d] pyridazine-4(5Н)-ones from 7-(2-furyl)-2-pyrrolidin-1-yl[1,3]thiazolo[4,5-d]pyridazin-4(5H)-one by alkylation with N-substituted chloroacetamides. Structures and purity of obtained compounds was confirmed by 1H NMR spectroscopy and liquid chromatography spectrometric analysis. Analgesic activity was investigated by in vivo tests on «Hot plate» and «acetic acid cramps» models. It is shown, that electron donor substituents in 4- and 2,4- positions of aryl fragment at the amide nitrogen atom of the 5-th position of the heterocyclic system give stronger analgesic effect of 5-N-substituted 7-(2-furyl)-2-pyrrolidin-1-yl[1,3]thiazolo[4,5-d]pyridazin-4(5H)-ones.