M. Lopp, A. Lopp, A. Paju
Jul 21, 1994
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Quality indicators
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract 15-Oxo metabolites of prostaglandins E2, F2α and new 15-oxo prostaglandin analogues 5 and 7 were found to reveal higher antiproliferative activity than the corresponding 15-hydroxy derivatives on human leukemia K562 cells in vitro. The responsibility of the enone group in the ω-chain of a prostanoid molecule for this activity is suggested.