V. A. Glushkov, K. Arapov, O. N. Minova
Jul 1, 2006
Citations
0
Influential Citations
13
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
A series of 1-aryl-3,3-dimethyl-3,4-dihydroisoquinolines were obtained by three-component (one-pot) condensation of veratrole, isobutylene oxide, and aromatic nitriles and then reduced to the corresponding 1,2,3,4-tetrahydroisoquinolines. Hydrochlorides of the synthesized compounds were tested for anticoagulant activity.