K. Kopanska, A. Najda, J. Żebrowska
May 15, 2004
Citations
2
Influential Citations
102
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.