I. G. Mobio, A. T. Soldatenkov, V. Fedorov
Apr 1, 1989
Citations
0
Influential Citations
4
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
The synthesis and examination of the steric structure and physiological activity of y-piperidones and y-piperidols have been the subject of many reports [8, 10, 12]. There is, however, little information on 4-oxo(hydroxy, amino)piperidines with aryl substituents in the a,~',8-positions. A modified Mannich reaction [9, ii, 13] has been used to obtain some novel 3-phenyl-2,6-diaryl-4-oxopiperidines. Benzaldehyde, p-bromo-, and para-methoxybenzaldehyde, and salicylaldehyde have been condensed with methyl benzyl ketone or methyl 8-phenethyl ketone and ammonia or methylamine. In order to obtain compounds with bactericidal, fungicidal, and herbicidal activity from y-piperidones (I, II, IV-VI), their oximes (XVI-XX) and secondary y-piperidols (IX-XIV) were obtained. The oximes were reduced to the amines (XXII-XXV).