Zhu Linhua
2013
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Journal
Chinese Journal of Pesticide Science
Abstract
Six novel 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)ethyl benzoates were synthesized by condensation of 2-(2-hydroxyethyl)benzo[d]isothiazol-3(2H)-one with substituted benzoic acids.All compounds were characterized by IR,1H NMR,ESI-MS and elemental analysis.The organisms used in the biological activity assay included gram-positive bacteria(Bacillus subtilis,Staphylococcus aureus,Staphylococcus albus) and gram-negative bacteria(Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa).The results showed that most of the compounds exhibit excellent inhibition activity against B.subtilis and S.aureus with MIC50 value about 4 mg/L.