L. Mallesha, K. Mohana
May 15, 2014
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Abstract
A series of new 2,4-difluorophenyl(piperidin-4-yl)methanone oxime derivatives 4a-h and 5a-e were synthesized by the reaction of 2,4-difluorophenyl(piperidin-4-yl)methanone oxime with various sulfonyl and acid chlorides. The synthesized compounds were characterized by elemental analyses, FT- IR, 1 H NMR and LCMS spectral studies. All compounds were evaluated for in vitro antibacterial and antifungal activities. Compounds 4b, 4g and 5e exhibited good antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound 4b would be a more activity deserves further research.