R. Hunashal, P. Ronad, V. Maddi
Dec 1, 2014
Citations
1
Influential Citations
35
Citations
Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
Abstract The title compounds 3a – l have been synthesized by the reaction of thiocarbohydrazide with substituted phenoxy acetic acid to obtained substituted 1,2,4-triazoles ( 1) . Compound 1 was treated with various substituted aromatic aldehydes which results in 4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-2 H -1,2,4-triazol-3(4 H )-thiones (2a – g) , further 2a – g is converted to 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4 H -1,2,4-triazol-3-yl thio] acetic acid (3a – l) derivatives by the reaction with chloroacetic acid. All the newly synthesized compounds were evaluated for in vivo anti-inflammatory and analgesic activities. Among the series 2-[4-(2,4-dichlorobenzylideneamino)-5-(phenoxymethyl)-4 H -1,2,4-triazol-3-yl thio] acetic acid (3d) , 2-[4-(4-dichlorobenzylideneamino)-5-(phenoxymethyl)-4 H -1,2,4-triazol-3-yl thio] acetic acid (3e) , 2-[4-(2,4-dichlorobenzylideneamino)-5-[(2,4-dichlorophenoxy)methyl]-4 H -1,2,4-triazol-3-yl thio] acetic acid (3j) and 2-[5-[(2,4-dichlorophenoxy)methyl)]-4-(4-chlorobenzylideneamino)-4 H -1,2,4-triazol-3-yl thio] acetic acid (3k) showed significant anti-inflammatory activity with P 3j , 3k exhibited significant analgesic activity with P