F. Babichev, V. K. Patratii, V. Kovtunenko
May 1, 1990
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Journal
Pharmaceutical Chemistry Journal
Abstract
Interest in the chemistry of isoquinolines with partially hydrogenated pyridine rings is due to their high biological activity. Specifically, protonated salts of l-R-3-dimethylamino-l,4-dihydroisoquinolines have been claimed as drugs for the treatment of allergic and rheumatic conditions [3]. With the aim of identifying biologically active compounds, we have developed a method of synthesis of novel isoquinolines [i]. Using this method, from o-(bromomethyl)phenylacetonitrile (I) and the p-substituted arylamines (Ia-f) there have been obtained the 2-(p-R-phenyl)-l,4-dihydroisoquinolin-3-imine hydrobromides (IIIa-f). We have now extended the range of this method to the mand o-substituted arylamines (IIg-j).