M. van Rensburg, E. Leung, Natalie A. Haverkate
Jan 15, 2017
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0
Influential Citations
13
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
3-Amino-2-arylcarboxamide-thieno[2,3-b]pyridines are a known class of antiproliferative compounds with activity against the phospholipase C enzyme. To further investigate the structure activity relationships of these derivatives a series of analogues were prepared modifying key functional groups. It was determined that modification of the 3-amino and 2-aryl carboxamide functionalities resulted in complete elimination of activity, whilst modification at C-5 allowed compounds of greater activity to be prepared.