J. Secrist, K. Tiwari, J. M. Riordan
Aug 1, 1991
Citations
1
Influential Citations
127
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.