Abdel-Ghany A. El-Helby
2002
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Journal
Pakistan journal of scientific and industrial research
Abstract
The potassium salt(1) of 5-chlorobenzoxazole-2-thione was prepared and allowed to react with alkyl chloroacetate and alkyl 3-chloro-propionate to afford II 1 - 1 0 .Compound II 2 was allowed to react with ammonia and hydrazine hydrate to afford III 1 1 and III 1 2 respectively. The compound III 1 2 was also reacted with the appropiate aldehydes to afford compounds IV 1 3 - 1 9 . The potassium salt(1) was also reacted with chloro-acetanilides to afford compounds V 2 0 - 3 9 . Preliminary pharmacological testing of some of these compounds showed that they exhibit anticonvulsant activity. The structure of these compounds was confirmed by elemental analysis IR, 1 HNMR and in some cases by MS spectral data.