V. Bolotov, A. Nambelbai, S. Drogovoz
Dec 1, 1985
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Journal
Pharmaceutical Chemistry Journal
Abstract
Continuinga search for compounds whith biological activity in 2-oxoindolines, we have synthesized 3,3adiphenyl-4 and 5-carboxy-2-oxoindoline-l-acetic acids (IIIa, b). The starting materials used in the syntheses were esters of 3,3-diphenyl-2-oxoindoline-4and 5-carboxylic acids (Ia, b) [2]. Reaction of the latter with ethyl chloroacetate in the presence of sodium ethoxide afforded the ethyl esters of 3,3-diphenyl-4and 5-ethoxycarbonyl-2-oxoindoline-l-acetic acids (IIa, b).