B. F. Abdel-Wahab, H. Mohamed, G. Awad
Dec 7, 2014
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Journal
European Chemical Bulletin
Abstract
A new series of 3-(4-fluorophenyl)-benzo[ g ]indazoles derivatives have been synthesized by simple, high yielding routes. The key step in the construction of the 3-(4-fluorophenyl)-benzo[ g ]indazoles nucleus involves the reaction of α-tetralone with 4-flurobenzaldehyde followed by reaction with hydrazine or thiosemicarbazide. The newly synthesized compounds were evaluated for their antimicrobial activity and compounds 5 , 6b , 12d and 16b demonstrated inhibitory effects on the growth of a wide range of microbes.