P. Verhaeghe, N. Azas, M. Gasquet
Jun 10, 2008
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Influential Citations
135
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Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodium falciparum strains, and the selectivity indexes for THP1 and HepG2 human cells were also calculated, revealing their antiplasmodial potential.