Kushal Lanjewar, A. Rahatgaonkar, M. Chorghade
Dec 1, 2009
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Influential Citations
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Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
A series of hybrid 5-(2-aminothiazol-4-yl)-3,4-dihydro-4-phenyl pyrimidin-2(1H)-ones (ATDPP) are reported. Efficient cyclocondensation of appropriately substituted 5-(2-bromoacetyl)-3,4-dihydro-4-phenylpyrimidine-2(1H)-ones (BADPP) with thiourea in ethanol proceeds in high yield to furnish the corresponding ATDPPs. Dihydropyrimidine carboxylates (DHPMS) and their bromo derivatives are the key substrates for cyclocondensation. The ATDPPS revealed biological activity as antimicrobial and antifungal agents against S. aureus, P. aurogenosa, K. pneumonae and C. albicans.