I. Yalcin, E. Şener, T. Özden
Oct 1, 1990
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0
Influential Citations
70
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
The synthesis and microbiological activity of a series of 5-methyl-2-(p-substituted phenyl)benzoxazoles 7a–7g are described. The in vitro microbiological activity of these compounds was determined against some Gram-positive and Gram-negative bacteria and C albicans. The observed minimum inhibitory concentration (MIC) values of the derivatives were compared to some other 2,5-disubstituted benzoxazoles and clinically used drugs. The in vitro microbiological data showed that the derivatives 7a–7g exhibited a broad spectrum of antibacterial activity and 7a–c and 7g were significantly active against E coli and/or K pneumoniae at an MIC of 6.2 μg/ml.