A. Kamal, B. S. P. Reddy, D. Thurston
Apr 1, 1993
Citations
0
Influential Citations
4
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
The synthesis of 5-thioabbeymycin (7) by a modified iminothioether route is described. This analog of abbeymycin exhibits potent antimicrobial activity. Attempts to synthesize the natural product abbeymycin (8) by reduction of 2(S)-hydroxy-11-S-methylpyrrolobenzodiazepine 4b with Al-Hg amalgam gave the overreduction product (6) as the only isolable product.