C. Mcguigan*, M. Slater, N. Parry
Apr 3, 2000
Citations
0
Influential Citations
22
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
We describe a synthesis of acyclovir-5'-(phenyl methoxy alaninyl) phosphate (2) from acyclovir (1). This compound was designed to act as a lipophilic, membrane-soluble prodrug of the free nucleotide. However, the biological activities of this derivative against a range of viruses indicated poor intracellular phosphate delivery, in marked contrast to the earlier successful delivery of several dideoxy anti-HIV nucleotides.