M. Ahsan, M. Amir, Mohamed Afroz Bakht
Sep 1, 2016
Citations
1
Influential Citations
13
Citations
Journal
Arabian Journal of Chemistry
Abstract
Abstract A series of 16 N 1 -(3-chloro-4-fluorophenyl)- N 4 -substituted semicarbazone derivatives were synthesized and subjected to computational pharmacokinetic studies to predict molecular properties. All the title compounds ( 4a – p ) followed the Lipinski “Rule of Five”. The synthesized compounds were characterized by elemental analyses and spectral data and the compounds ( 4a – p ) were evaluated for antimicrobial activities. Among them the compound 2-(4-hydroxybenzylidene)- N -(3-chloro-4-fluorolphenyl)hydrazinecarboxamide ( 4f ) was found to be the most active compound that showed good antibacterial activity while the compound 2-(4-methoxybenzylidene)- N -(3-chloro-4-fluorolphenyl)hydrazinecarboxamide ( 4g ) was moderately active against fungal strains. We have noticed that the compounds, ( 4f , 4k and 4d ) bearing OH and NO 2 groups on the phenyl ring at position 4 exhibited good antibacterial activity while compound ( 4g ) bearing OCH 3 on the phenyl ring at position 4 exhibited moderate antifungal activity.