B. Japelj, S. Rečnik, P. Čebašek
Sep 1, 2005
Citations
0
Influential Citations
25
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A series of alkyl l-heteroaryl-1H-1,2,3-triazole-4-carboxylates 6a-u were synthesised in four steps from methyl (Z)-2-benzyloxycarbonylarmino-3-(dimethylamino)prop-2-enoate (1) and heterocyclic amines 2a-s. Triazoles 6a-o were tested against antimycobacterial activity. For the most active compound, n-pentyl 1-(6-phenylpyridazin-3-yl)-1H-1,2,3-triazole-4-carboxylate (6n), minimum inhibitory concentration 3.13 μg/ml was determined.