S. Naruto, S. Ueda, T. Yoshida
May 25, 1987
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
Several aminoalkyl esters of 2- (1, 2-benzisoxazol-3-yl) -2-cyclohexylacetic acid, 1- (1, 2-benzisoxazol-3-yl) -1-cyclopentanecarboxylic acid, and 1- (1, 2-benzisoxazol-3-yl) -1-cyclohexanecarboxylic acid and their quaternary ammonium salts were synthesized. The anticholinergic (anti-Ach) and musculotropic (anti-KCl) activities of these compounds were examined. Among them, 3- (N, N-diethylamino) -propyl 2- (1, 2-benzisoxazol-3-yl) -2-cyclohexylacetate (8b) showed potent anti-Ach and anti-KCl activities.