Liu Chang-chun
2013
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Journal
Chemical Reagents
Abstract
A series of aroylthioureas containing 2-chloro-5methylpyridine moiety were synthesized efficiently by one-pot reaction of aroyl chloride and(2-chloropyridin-5-yl) methyl amine using ionic liquid 1-butyl-3-methylimidazolium thiocyanate([Bmim]SCN) both as an initial material and reaction solvent.The structures were confirmed by 1HNMR and IR,and biological activities were also originally studied.The desired compounds were obtained in 82.7% ~ 95.6% yields when 10.0 mmol aroyl chloride was reacted with 11.0 mmol [Bmim]SCN for 10 min at room temperature,and then added 10.5 mmol(2-chloropyridin-5-yl) methyl amine continued to react for 20 min at room temperature.[Bmim]SCN could be recycled at least six times without significant decrease in yield.Preliminary biological tests indicated that some target compounds have fungicidal and plant growth regulative activity.