F. Babichev, V. K. Patratii, Y. Volovenko
Oct 1, 1988
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Journal
Pharmaceutical Chemistry Journal
Abstract
The purpose of this work was the search for biologically active compounds in the series of =-(halohetaroyl)-2-azahetarylacetonitriles (I-XII) and the determination of the relationship between structure and antibacterial and antifungal activities. Compounds I-XII were prepared by acylation of 2-cyanomethyl derivatives of pyridine, l-methylbenzimidazole, 4methylthiazole, quinoline, and benzthiazole with the acid chlorides of 3,4,5-trichlorothiophene-2-carboxylic acid, 3,6-dichloropyridazine-4-carboxylic acid, and of derivatives of