O. Hishmat, A. M. Nasef, S. I. El-Naem
Dec 1, 1989
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Journal
Archives of Pharmacal Research
Abstract
The reaction of the sodium salts of 4-methoxy and 4,7-dimethoxy 6-hydroxy-benzofuran-5-carboxylic acid with ethyl chloroformate yields the corresponding dicarbethoxy derivatives. The N-substituted amides were obtained by treating the latter compounds with amines. The corresponding hydrazides were synthesized by the reaction of hydrazine hydrate on the dicarbethoxy derivatives which spontaneously cyclized to 5-substituted-2,3-dihydro-1,3,4-oxadiazol-2-one. Also the reaction with phenyl hydrazine has been studied. The dicarbethoxy derivatives and N-substituted amides were tested against Gram positive and Gram negative bacteriain vitro. Most of the compounds possess moderate or slight activity against Gram positive bacteria.