L. Mosti, G. Menozzi, P. Schenone
Sep 1, 1989
Citations
0
Influential Citations
30
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract The synthesis of ethyl and methyl esters of 2-substituted 5-cyano-1,6-dihydro-6-oxo-3-pyridinecar☐ylic acids by reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with sodium cyanoacetamide is described. These esters gave by alkaline hydrolysis the corresponding car☐ylic acids, which were decar☐ylated to 6-substituted 1,2-dihydro-2-oxo-3-pyridinecarbonitriles. As milrinone analogues, nearly all the above compounds were tested on contractile activity and frequency rate of spontaneously beating atria and electrically driven left atria from guinea pigs. Among the esters, ethyl 5-cyano-1,6-dihydro-2-methyl-6-oxo-3-pyridinecar☐ylate induced positive inotropic and chronotropic effects superior to those caused by milrinone. By increasing or branching the 2-substitutent, the activity decreased until faded or even reversed. Car☐ylic acids and nitriles were less active than milrinone. Some aspects of the structure-activity relationship of these compounds are discussed on the basis of X-ray structural analyses of 2-methyl, 2- t -butyl and 2-phenyl esters.