Sakineh Asghari, S. Ramezani, M. Mohseni
Mar 1, 2014
Citations
0
Influential Citations
23
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract The three-component reaction of 4-hydroxy-1-methyl-2(1 H )-quinolinone, aromatic aldehydes and ethyl cyanoacetate was carried out in the presence of a catalytic amount of 4-dimethyl aminopyridine (DMAP) in aqueous ethanol. The reactions result in the formation of pyranoquinoline derivatives in excellent yields. Antibacterial activity has been evaluated against Gram positive and Gram negative bacteria for some of the synthesized compounds. The results indicated that these compounds are moderately effective against bacterial growth and their effectiveness is highest against Pseudomonas aeruginosa .