Zeng Guang-xian
2013
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Journal
Science and Technology of Food Industry
Abstract
A novel antibacterial agent,ethyl N-[1-oxo-2,4-hexadien-1-yl]-L-phenylalaninate was synthesized.Excellent synthetic yield were studied through optimization of the conditions,such as reaction time,temperature and the ratio of L-phenylalaninate and SOCl2.When the reaction time was 3.5h,the reaction temperature was 60℃,the ratio of L-phenylalaninate and SOCl2 was 1∶3.2,the synthetic yield of L-phenylalaninate ethyl ester hydrochloride could reach 93.8%.The antimicrobial activity of ethyl N-[1-oxo-2,4-hexadien-1-yl]-L- phenylalaninate against Escherichia coli,Bacillus subtili,Staphylococcus aureus the mixed bacteria from rancidity milk was studied and its minimum inhibitory concentrations of ethyl N-[1-oxo-2,4-hexadien-1-yl]- L-phenylalaninate against these bacterial strains were 2.50,0.75,2.00 and 2.50mmol/L respectively.Its antibacterial activity was much better than sorbic acid.At the same time,ethyl N-[1-oxo-2,4-hexadien-1-yl]-L-phenylalaninate still exhibited good antibacterial activity in alkaline condition.The growth adaptation period of the mixed bacteria from rancidity milk could be prolonged to 36h.