Die Cheng, Dengke Liu, Mo Liu
Sep 1, 2008
Citations
0
Influential Citations
3
Citations
Journal
Chinese Chemical Letters
Abstract
A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3, 2-c] pyridine were synthesized and structurally characterized by 1H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design.