Ivana Zemanov, Renata Gaparov, Andrej Bohč
Oct 16, 2017
Citations
0
Influential Citations
4
Citations
Journal
Arkivoc
Abstract
8-Ethoxyfuro[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine was synthesized by reaction of appropriate triazinone with POCl3 and subsequent treating of 8-chloro derivative with sodium ethoxide in ethanol. Furo[3,2-b]pyrrole-5carboxylates were hydrolysed to form acids, which underwent one-pot decarboxylation with TFA and formylation of the in situ formed furo[3,2-b]pyrrole with triethyl orthoformate to give 5-carbaldehydes. Hydrazinolysis of bis-esters led to bis-carbohydrazides which subsequently cyclized in acetic acid under microwave irradiation to form either pyrazine or acetamide derivatives with unusual chirality. Prepared compounds were evaluated for their antibacterial activity on Escherichia coli and Micrococcus luteus.