A. B. Ghattas, H. M. Moustafa, Elsayed E. A. Hassanein
Nov 1, 2016
Citations
1
Influential Citations
16
Citations
Journal
Arabian Journal of Chemistry
Abstract
Abstract 4-Anilino-5-phenyl-4 H -1,2,4-triazole-3-thiol ( 1 ) reacted with formaldehyde and different amines to give Mannich bases 2a – i . Treatment of compound 1 with formaldehyde afforded the corresponding 2-hydroxymethyl derivative 3 , which upon its reaction with thionyl chloride yielded the corresponding chloromethyl derivative 4 . Treatment of compound 4 with some thiols gave the corresponding sulfides 5a – f . The ring closure reaction of chloromethyl derivative 4 with hydrazine hydrate, phenyl hydrazine, hydroxylamine, urea and thiourea afforded triazolo-, oxadiazolo- and triazinotriazoles 6 – 10 , respectively.