M. Lhassani, O. Chavignon, J. Chezal
Mar 1, 1999
Citations
0
Influential Citations
172
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract Imidazo[1,2- a ]pyridines bearing a 3-(dithiolan-, dioxolan- or oxathiolan-2-yl) substituent were synthesized from the corresponding aldehydes. The dithiolanyl derivative 6a proved active against cytomegalovirus at an inhibitory concentration (IC 50 ) of 16 μM, whilethe oxathiolanyl compound 6c inhibited respiratory syncytial virus (IC 50 : 58 μM). The thioacetal 7 was active against cytomegalovirus at an IC 50 of 3.1 μM. None of the compounds had anti-HIV activity and were not inhibitory against other RNA and DNA viruses evaluated. Compounds 6a,c and 7 had in vitro selectivity indexes (ratio cytostatic concentration/antivirally active concentration) ranging between 8 and 10.