N. F. Kirillov, R. R. Makhmudov, E. A. Nikiforova
Dec 1, 2012
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Journal
Pharmaceutical Chemistry Journal
Abstract
Methyl-1-(1-aryl-3-arylamino-3-oxo-2-cyanopropyl)cyclohexane carboxylates were prepared by reaction of methyl-1-bromocyclohexane carboxylates with zinc and arylamides of 3-aryl-2-cyanopropenoic acids. The synthesized compounds possessed analgesic activity and had low toxicity.